CD34

CD34
識別子
記号	CD34, entrez:947, CD34 molecule
外部ID	OMIM: 142230 MGI: 88329 HomoloGene: 1343 GeneCards: CD34
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	207,911,402 bp
遺伝子の位置 (マウス)
染色体	1番染色体 (マウス)
終点	194,643,587 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 転写因子結合; • sulfate binding; • 炭水化物結合;
細胞の構成要素	• 細胞質; • integral component of membrane; • 膜; • 細胞膜; • integral component of plasma membrane; • 細胞外領域; • cell surface; • basal plasma membrane; • glomerular endothelium fenestra; • apical plasma membrane; • intercellular bridge; • perinuclear region of cytoplasm; • リソソーム; • external side of plasma membrane; • 細胞周辺;
生物学的プロセス	• extracellular exosome assembly; • stem cell proliferation; • positive regulation of interleukin-10 production; • cell motility; • negative regulation of blood coagulation; • metanephric glomerular mesangial cell differentiation; • 傍分泌シグナル伝達; • hematopoietic stem cell proliferation; • positive regulation of granulocyte colony-stimulating factor production; • 遺伝子発現の負の調節; • positive regulation of angiogenesis; • regulation of blood pressure; • vascular wound healing; • positive regulation of gene expression; • glomerular filtration; • negative regulation of nitric oxide biosynthetic process; • 細胞接着; • endothelial cell proliferation; • mesangial cell-matrix adhesion; • tissue homeostasis; • positive regulation of vasculogenesis; • endothelium development; • regulation of immune response; • negative regulation of cellular response to heat; • positive regulation of transforming growth factor beta production; • glomerular endothelium development; • negative regulation of tumor necrosis factor production; • cell-matrix adhesion; • 細胞増殖; • positive regulation of odontogenesis; • negative regulation of cellular response to hypoxia; • leukocyte migration; • シグナル伝達; • 分化転換; • negative regulation of neuron death; • cell-cell adhesion; • 造血;
	出典:Amigo / QuickGO
オルソログ
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001025109; NM_001773
	NM_001111059; NM_133654
	NP_001020280; NP_001764
	NP_001104529; NP_598415
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

CD34（cluster of differentiation 34）は、ヒト、マウス、ラットやその他の種においてCD34遺伝子にコードされる膜貫通型リン酸化糖タンパク質である^[5]^[6]^[7]。

CD34という名称は、細胞表面抗原を特定するCD分類に由来する。CD34はCivinらとTindleらによって独立に、造血幹細胞において細胞間接着因子として機能する細胞表面糖タンパク質として記載された^[8]^[9]^[10]^[11]。CD34は造血幹細胞を骨髄の細胞外マトリックスへ、もしくは直接的に間質細胞へ接着を媒介している可能性がある。臨床的には、CD34は骨髄移植のための造血幹細胞の選別や増幅と関係している。こうした組織学的・臨床的関連により、CD34の発現は造血幹細胞と関連付けられることが多いが、実際にはCD34は他の多くの細胞種にも存在している^[12]。

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Entrez Gene: CD34 CD34 molecule”. 2023年3月11日閲覧。
^ “Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells”. Journal of Immunology 148 (1): 267–271. (January 1992). PMID 1370171.
^ “Structure of the gene encoding CD34, a human hematopoietic stem cell antigen”. Genomics 12 (4): 788–794. (April 1992). doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
^ “Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells”. Journal of Immunology 133 (1): 157–165. (July 1984). PMID 6586833.
^ “A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow”. Leukemia Research 9 (1): 1–9. (1985). doi:10.1016/0145-2126(85)90016-5. PMID 3857402.
^ Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). “BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .”. In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.
^ Loken M. Shah V. Civin CI.. (1987). “Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence”. In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.
^ “Concise review: evidence for CD34 as a common marker for diverse progenitors”. Stem Cells 32 (6): 1380–1389. (June 2014). doi:10.1002/stem.1661. PMC 4260088. PMID 24497003.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[:1-5] “Entrez Gene: CD34 CD34 molecule”. 2023年3月11日閲覧。

[pmid1370171-6] “Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells”. Journal of Immunology 148 (1): 267–271. (January 1992). PMID 1370171.

[pmid1374051-7] “Structure of the gene encoding CD34, a human hematopoietic stem cell antigen”. Genomics 12 (4): 788–794. (April 1992). doi:10.1016/0888-7543(92)90310-O. PMID 1374051.

[:2-8] “Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells”. Journal of Immunology 133 (1): 157–165. (July 1984). PMID 6586833.

[:3-9] “A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow”. Leukemia Research 9 (1): 1–9. (1985). doi:10.1016/0145-2126(85)90016-5. PMID 3857402.

[:4-10] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). “BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .”. In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.

[:5-11] Loken M. Shah V. Civin CI.. (1987). “Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence”. In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.

[:0-12] “Concise review: evidence for CD34 as a common marker for diverse progenitors”. Stem Cells 32 (6): 1380–1389. (June 2014). doi:10.1002/stem.1661. PMC 4260088. PMID 24497003.

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